Previously: Epigenetics and epigenomics. About the module name changes
About this module
The completion of the human genome project has paved the way for major advances in our understanding of human genetic disease and the pathogenesis of cancer. Nevertheless, these advances have also revealed that genetics is only part of the story and there is increasing recognition that epigenetics will be critical for understanding human disease and the practice of genomic medicine. Cambridge is the leading European centre for epigenetic research and this module will draw on world-leading local scientists to provide expert coverage of this fascinating topic.
Before the module
Suggested preparation
Module-specific materials and instructions are provided through your course Moodle/VLE. These refreshers are optional support, not additional assessment requirements.
What you will study
- Definition and history of epigenetics
- Elements of epigenetic gene regulation: chromatin packaging, nucleosomes, histone marks, establishment and maintenance of DNA methylation, non-coding RNAs etc.
- Methodologies for investigating epigenetics regulation in health and disease
- Genomic resources for epigenetic research and interpretation. The Epigenome Project
- Role of model organisms in elucidating epigenetic control mechanisms
- Mechanisms of epigenetic regulation of gene expression in normal development (including nuclear reprogramming, X-chromosome inactivation and genomic imprinting)
- Epigenetics and inherited disease: inherited disorders caused by mutations in genes regulating epigenetic processes, human imprinting disorders, assisted reproductive technologies
- Epigenetics and acquired disease: epigenetics and cancer, epigenetics and gene/environmental interactions, epigenetics and ageing
- Epigenetics and therapeutics
Learning objectives
By the end of this module you will be able to:
- Understand the role of epigenetic factors in regulating gene expression
- Appreciate the critical role of epigenetics in normal development and human health
- Critically appraise methodologies for epigenetic studies of human disease
- Understand the role of epigenetic abnormalities in human disease, and in particular, the role in inherited disorders and neoplasia
- Describe the relevance of epigenetics for gene-environment interactions and the significance of epigenetics for therapeutic strategies for human diseases such as cancer
Teaching
12–16 April 2027
School of Clinical Medicine, Hills Road, Cambridge CB2 0QQ
Learning objectives follow the 2026–27 curriculum, including programme-team updates.